DUTCH CYCLE MAPPING PLUS (FEMALE ONLY)
Cycle Mapping™ PLUS combines the full picture of a woman’s cycle and adds salivary measurements of the Cortisol Awakening Response (CAR) to bring another important piece of the HPA axis
into focus and answer important questions for patients with month-long symptoms, infertility, and PCOS.
WHAT IS CYCLE MAPPING™ PLUS?
The DUTCH Cycle Mapping™ PLUS not only maps estrogen and progesterone through the monthly menstrual cycle, but also adds the comprehensiveness of all the hormone metabolites along with the cortisol awakening response (CAR).
Hormonal balance is key. Fluctuating levels of estradiol and progesterone play a major role in a woman’s overall health. This panel is designed for cycling women who struggle with ongoing symptoms such as monthly migraines, fertility issues, or PCOS. The addition of the cortisol awakening response (CAR), a transient, immediate rise in cortisol upon awakening (distinct from the diurnal rhythm), provides a fuller assessment of hormone fluctuations, baseline stress response, and reflects a patient’s ability to cope with anticipated challenges. CAR also shows a patient’s perception of control around chronic stress, providing insight into HPA resiliency.
WHEN IS CYCLE MAPPING™ PLUS RECOMMENDED?
• Women struggling with infertility
• Women with cycling hormones and no menses
• Partial hysterectomy (ovaries intact but no uterus)
• Women with irregular cycles
• If the luteal phase shifts from month-to-month
• Not sure when to test due to long or short cycles
• Women whose hormonal symptoms tend to fluctuate throughout the cycle
• PMS, mid-cycle spotting, migraines, etc.
WHEN IS CYCLE MAPPING™ PLUS NOT NEEDED? (DUTCH COMPLETE™ IS SUFFICIENT)
• Postmenopausal women
• Women on birth control
• Women with cycles that follow the expected pattern
MOST CONVENIENT METHOD FOR MONTH-LONG ANALYSIS
EASY SAMPLE COLLECTIONS MAKE FOR BETTER TESTING
DUTCH Cycle Mapping™ PLUS uses more sample collections for mapping (first-morning urine collections) and performs testing on targeted samples based on the actual length of the cycle. In addition, one full day of four (4) urine and five (5) saliva samples are collected, providing the comprehensive hormone metabolite and cortisol awakening response (CAR) results.
WHAT CAN INCLUDING THE DUTCH PLUS® AND C.A.R. TELL YOU?
Even though a patient may have “normal” free cortisol levels throughout the day, that does not always mean everything is functioning properly. The graph below shows two good examples. A blunted or exaggerated CAR can appear even when single samples return “normal” results. The HPA axis might not be appropriately responding when faced with a stressor, even when cortisol levels are fluctuating nicely throughout the day.
This kit includes:
Easy collection instructions
25 urine filter paper collection strips
6 SalivetteTM saliva collection tubes
Requisition form for patient information, pertinent supplements, medications, hormone replacement and a health questionnaire
Sealable return envelope
The results include:
Nine targeted estrogen and progesterone measurements throughout the cycle to characterize the follicular, ovulatory and luteal phases
Analysis of 35 different hormones: estrogen, progesterone, testosterone, DHEA-S, and cortisol along with their metabolites. Plus the cortisol awakening response (CAR)
Graphical representation of results and embedded video tutorials to assist in the hormone test analysis to share with your medical provider
DUTCH OATs: Oxidative Stress Marker – 8-Hydroxy-2-deoxyguanosine (8-OHdG), melatonin (6OHMS), and six organic acid tests (OATs) including markers for vitamin B12 (methylmalonate), vitamin B6 (xanthurenate), kynurenate, glutathione (pyroglutamate), dopamine (homovanillate), norepinephrine/epinephrine (vanilmandelate).
DUTCH Cycle Mapping PLUS info sheet
DUTCH Cycle Mapping PLUS sample report